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醫(yī)學(xué)翻譯-組織病理學(xué)變化翻譯
Unitrans世聯(lián)
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翻譯:Histopathological Changes
高、中、低三個(gè)劑量組動物于非連續(xù)給藥后第14天和第28天后活殺,每組動物10只,雌雄各半,經(jīng)30余種臟器組織的系統(tǒng)病理組織學(xué)觀察表明:高劑量組分別見少數(shù)散在性局灶性點(diǎn)灶狀輕度心肌纖維呈嗜酸性變(14天見于5/10只,28天見于7/10只,28天組病變范圍略較14天組增大);胸腺輕度萎縮,皮質(zhì)輕度變。14天見于1/10只,28天見于4/10只,28天組病變程度較14天組明顯);脾小體少數(shù)淋巴細(xì)胞核固縮碎裂(僅見于28天組3/10只,未見于14天組);淋巴結(jié)淋巴濾泡少數(shù)淋巴細(xì)胞核固縮碎裂(14天和28天各見1/10只),骨髓腔分葉核粒細(xì)胞輕度減少(14天組見于1/10只。28天組見于4/10只);
翻譯:The animals in the high-, middle- and low-dose groups were killed 14 days and 28 days after the discontinuous administration, with 10 animals in each group (5 male and 5 female). Over 30 organs and tissue underwent systematic histopathologic observation, indicating that the animals in the high-dose group respectively had disseminated focal spot mild acidophilic degeneration of a few cardiac muscle fibers (observed in 5/10 rats on the 14th day, in 7/10 on the 28th day, and the range of pathological changes on the 28th day was slightly larger than that on the 14th day); Thymus had mild atrophy and cortex had mild thinning (observed in 1/10 rats on the 14th day, in 4/10 rats on the 28th day, and the degree of pathological changes on the 28th day was more remarkable than that on the 14th day); A few lymphocytes in splenic corpuscle suffered from karyopyknosis and nuclear fragmentation (observed only in 3/10 rats on the 28th day, and not observed on the 14th day); A few lymphocytes in lymphoid follicles of lymph nodes suffered from karyopyknosis and nuclear fragmentation (observed in 1/10 rats respectively on the 14th and 28th day), and segmented granulocytes in marrow cavity decreased slightly (observed in 1/10 rats on the 14th day, and observed in 4/10 rats on the 28th day);
肝少數(shù)點(diǎn)灶狀壞死,伴出血(僅見于28天組1/10只,未見于14天組);腎臟遠(yuǎn)曲小管輕度擴(kuò)張,上皮細(xì)胞輕度變性(14天組見于0/10只。28天組見于4/10只,其中1只少量蛋白管型);睪丸少數(shù)曲細(xì)精管生精上皮變薄,精原細(xì)胞輕度變性(14天組見于1/5只。28天組見于2/5只);卵巢成熟卵泡部分顆粒細(xì)胞變性(14天組見于1/5只。28天組見于4/5只);其他器官組織未見明顯病變。中劑量組上述病變僅發(fā)生在28天組,發(fā)生率明顯減少(心、胸腺、骨髓、腎、睪丸、卵巢各1只),程度明顯減輕。低劑量組所有動物的器官組織均未見明顯損傷。停藥后1個(gè)月,高劑量組除1只動物腎小管輕度擴(kuò)張和少量蛋白管型、1只動物小葉性局灶性肺炎外,其余動物各臟器均未見明顯變化,提示給藥14天和28天的大部分臟器損傷均已恢復(fù);中、低劑量組均未見明顯病變。